All analyses 
were performed playing with SAS type 9.cuatro (SAS Institute, Cary, Vermont). We performed complete case analyses, since the none of your own parameters had >5% lost.
Abilities
I incorporated a maximum of 6354 girls (1574 vaccinated [?1 dosage], 4111 unvaccinated, and you will 669 unfamiliar, most of the thinking-reported) and you will 2414 heterosexual men just who all the offered a genital swab; the analysis inhabitants is actually 1524 in ’09, 1775 in 2011, 1816 within the 2013, 1782 during the 2015, and you can 1871 when you look at the 2017. The fresh new part of ladies reporting to get vaccinated enhanced along the years; 2.3% during 2009, 6.4% last year, 19.2% in the 2013, 36.7% in the 2015, and you may 54.1% for the 2017. Overall, thirteen.2% away from vaccinated girls was in fact vaccinated when you look at the normal program. Attributes of overall research populace is actually shown in the Desk step one, into the association anywhere between properties and study 12 months as well as the organization between qualities and you may HPV positivity provided independently for everybody lady, heterosexual men, and you will unvaccinated ladies in Secondary Dining tables step 1–step three .
a high academic top integrated school out of higher standard secondary studies, pre–school education, school off applied sciences, and you can university. Low/center educational peak incorporated any quantities of training.
The x-axes differ between every woman, heterosexual people, and unvaccinated people
c Contradictory incorporated revealing never ever, barely, and you can “often I really do, possibly I don’t” condom explore. Consistent integrated revealing will otherwise constantly condom explore.
a high academic height provided school out-of high standard supplementary education, pre–university knowledge, university out of applied sciences, and you can college. Low/center academic level integrated any kind of quantities of education.
Brand new x-axes disagree ranging from every woman, heterosexual men, and you may unvaccinated people
c Contradictory provided revealing never, barely, and you may “often I really do, often I really don’t” condom explore. Consistent integrated revealing have a tendency to or constantly condom explore.
Figure step one screens the newest rough HPV incidence through the years for everybody ladies, heterosexual people, and you will unvaccinated ladies. HPV frequency are positively influenced by the brand new SHC policy change from 2015 forth. Immediately following modifications for age and you may changes in personal-peak functions over the years, plan alter is predicted to possess elevated the HPV sort of-particular positivity by 9% certainly females and up to help you 31% one of boys from inside the development analyses. Complete, once adjustment to have ages and you will picked new member characteristics, plus very after modifications for plan change, e healthier, and increase trend became weakened ( Second Desk 4 ). On the finally adjusted GEE models, decreasing manner in both vaccine versions HPV-16 and you will HPV-18 was basically estimated for women, heterosexual men, and unvaccinated women separately ( Contour dos). The brand new pooled percentual decline in HPV- frequency annually are 12.6% (95% depend on interval [CI], 10.6%–14.5%) certainly one of every woman, thirteen.0% (95% CI, 8.3%–17.5%) one of heterosexual males, and you may 5.4% (95% CI, dos.9%–seven.8%) among unvaccinated lady ( Dining table dos). Decreasing trends was indeed including seen to have mix-defensive designs. We estimated somewhat declining styles on incidence away from HPV-31, that have a good six.8% annual refuse (P Secondary Dining table cuatro . *HPV-68 also contains HPV-73 and you will HPV-97. #Part imagine getting HPV-34 one of heterosexual people was –26%. Regression coefficients for everyone girls was adjusted to have ages, plan alter at intimate health cardiovascular system, lifestyle intercourse people, reputation for people intimately sent issues (STI), constant companion, informed to own STI, sex people prior six months, and condom explore with informal companion. Regression coefficients to own heterosexual males were adjusted to possess age, coverage transform from the sexual wellness heart, life intercourse people, and you will reputation of one sexually carried problems. Regression coefficients to the unvaccinated female was in fact modified to have years, plan change during the sexual fitness cardiovascular system, life sex partners, reputation of one sexually carried problems, notified to possess STI, sex partners past 6 months, and you will condom have fun with having relaxed companion.
Pooled style was in fact acquired due to the fact good weighted average of one’s particular-specific style throughout the generalized quoting formula Poisson activities. Percentual improvement in incidence per year are computed from the exponentiating brand new modified regression coefficients of analysis 12 months.